Clam Antivirus (ClamAV) is probably the most well-known Linux/UNIX antivirus, but has a small draw-back for some: it's a command-line application. ClamTk comes to the rescue: it is a GUI front-end for Clam Antivirus.
Clam AntiVirus is an open source (GPL) anti-virus toolkit for UNIX, designed especially for e-mail scanning on mail gateways. It provides a number of utilities including a flexible and scalable multi-threaded daemon, a command line scanner and advanced tool for automatic database updates. The core of the package is an anti-virus engine available in a form of shared library.
ClamTk 4.19 was released yesterday and this release adds a unified preferences box. In doing so, you can remove the Load and Save Preferences options as well as clean up the initial interface and add extra preferences from which to choose.
Before installing ClamTk, make sure you have Clam Antivirus installed. For Ubuntu:
sudo apt-get install clamav
Then, download ClamTk 4.19 (.deb, .rpm and source files available).